Spinoculation and retronectin highly enhance the gene transduction efficiency of Mucin-1-specific chimeric antigen receptor (CAR) in human primary T cells

Abstract Background Producing an appropriate number of engineered cells is considered as one of the influential factors in the successful treatments with chimeric antigen receptor (CAR) T cells. To this aim, the transduction rate of the viral vectors can play a significant role. In addition, improvi...

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Auteurs principaux: Alireza Rajabzadeh, Amir Ali Hamidieh, Fatemeh Rahbarizadeh
Format: article
Langue:EN
Publié: BMC 2021
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Accès en ligne:https://doaj.org/article/15094b31441a4be193eacbf51293d0ca
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