Maternal iron deficiency perturbs embryonic cardiovascular development in mice
From mouse experiments, the authors link iron deficiency in mothers with cardiovascular defects and increased retinoic acid signalling in their offspring, and giving iron early in pregnancy can prevent most defects.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/151683b89d484445a2fc425e4f26bd68 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:151683b89d484445a2fc425e4f26bd68 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:151683b89d484445a2fc425e4f26bd682021-12-02T14:58:13ZMaternal iron deficiency perturbs embryonic cardiovascular development in mice10.1038/s41467-021-23660-52041-1723https://doaj.org/article/151683b89d484445a2fc425e4f26bd682021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23660-5https://doaj.org/toc/2041-1723From mouse experiments, the authors link iron deficiency in mothers with cardiovascular defects and increased retinoic acid signalling in their offspring, and giving iron early in pregnancy can prevent most defects.Jacinta I. Kalisch-SmithNikita VedDorota SzumskaJacob MunroMichael TroupShelley E. HarrisHelena Rodriguez-CaroAimée JacquemotJack J. MillerEleanor M. StuartMagda WolnaEmily HardmanFabrice PrinEva Lana-ElolaRifdat AoidiElizabeth M. C. FisherVictor L. J. TybulewiczTimothy J. MohunSamira Lakhal-LittletonSarah De ValEleni GiannoulatouDuncan B. SparrowNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jacinta I. Kalisch-Smith Nikita Ved Dorota Szumska Jacob Munro Michael Troup Shelley E. Harris Helena Rodriguez-Caro Aimée Jacquemot Jack J. Miller Eleanor M. Stuart Magda Wolna Emily Hardman Fabrice Prin Eva Lana-Elola Rifdat Aoidi Elizabeth M. C. Fisher Victor L. J. Tybulewicz Timothy J. Mohun Samira Lakhal-Littleton Sarah De Val Eleni Giannoulatou Duncan B. Sparrow Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| description |
From mouse experiments, the authors link iron deficiency in mothers with cardiovascular defects and increased retinoic acid signalling in their offspring, and giving iron early in pregnancy can prevent most defects. |
| format |
article |
| author |
Jacinta I. Kalisch-Smith Nikita Ved Dorota Szumska Jacob Munro Michael Troup Shelley E. Harris Helena Rodriguez-Caro Aimée Jacquemot Jack J. Miller Eleanor M. Stuart Magda Wolna Emily Hardman Fabrice Prin Eva Lana-Elola Rifdat Aoidi Elizabeth M. C. Fisher Victor L. J. Tybulewicz Timothy J. Mohun Samira Lakhal-Littleton Sarah De Val Eleni Giannoulatou Duncan B. Sparrow |
| author_facet |
Jacinta I. Kalisch-Smith Nikita Ved Dorota Szumska Jacob Munro Michael Troup Shelley E. Harris Helena Rodriguez-Caro Aimée Jacquemot Jack J. Miller Eleanor M. Stuart Magda Wolna Emily Hardman Fabrice Prin Eva Lana-Elola Rifdat Aoidi Elizabeth M. C. Fisher Victor L. J. Tybulewicz Timothy J. Mohun Samira Lakhal-Littleton Sarah De Val Eleni Giannoulatou Duncan B. Sparrow |
| author_sort |
Jacinta I. Kalisch-Smith |
| title |
Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| title_short |
Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| title_full |
Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| title_fullStr |
Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| title_full_unstemmed |
Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| title_sort |
maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/151683b89d484445a2fc425e4f26bd68 |
| work_keys_str_mv |
AT jacintaikalischsmith maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT nikitaved maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT dorotaszumska maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT jacobmunro maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT michaeltroup maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT shelleyeharris maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT helenarodriguezcaro maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT aimeejacquemot maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT jackjmiller maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT eleanormstuart maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT magdawolna maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT emilyhardman maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT fabriceprin maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT evalanaelola maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT rifdataoidi maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT elizabethmcfisher maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT victorljtybulewicz maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT timothyjmohun maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT samiralakhallittleton maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT sarahdeval maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT elenigiannoulatou maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice AT duncanbsparrow maternalirondeficiencyperturbsembryoniccardiovasculardevelopmentinmice |
| _version_ |
1718389308877963264 |