Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

TLR and IL-1R1 ligands are danger signals released following tissue injury and during the healing response. Here, the authors show that IL-1β signalling via IL-1R1/MyD88 inhibits the Akt/GSK-3β/β-catenin pathway in mesenchymal stem cells, which suppresses their mobilization, proliferation, and diffe...

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Autores principales: Mikaël M. Martino, Kenta Maruyama, Gisela A. Kuhn, Takashi Satoh, Osamu Takeuchi, Ralph Müller, Shizuo Akira
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/153147c9da8341d39d1128c501422b75
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