Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

TLR and IL-1R1 ligands are danger signals released following tissue injury and during the healing response. Here, the authors show that IL-1β signalling via IL-1R1/MyD88 inhibits the Akt/GSK-3β/β-catenin pathway in mesenchymal stem cells, which suppresses their mobilization, proliferation, and diffe...

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Autores principales:	Mikaël M. Martino, Kenta Maruyama, Gisela A. Kuhn, Takashi Satoh, Osamu Takeuchi, Ralph Müller, Shizuo Akira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/153147c9da8341d39d1128c501422b75
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spelling	oai:doaj.org-article:153147c9da8341d39d1128c501422b752021-12-02T14:39:32ZInhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration10.1038/ncomms110512041-1723https://doaj.org/article/153147c9da8341d39d1128c501422b752016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11051https://doaj.org/toc/2041-1723TLR and IL-1R1 ligands are danger signals released following tissue injury and during the healing response. Here, the authors show that IL-1β signalling via IL-1R1/MyD88 inhibits the Akt/GSK-3β/β-catenin pathway in mesenchymal stem cells, which suppresses their mobilization, proliferation, and differentiation into osteoblasts, processes necessary for bone regeneration.Mikaël M. MartinoKenta MaruyamaGisela A. KuhnTakashi SatohOsamu TakeuchiRalph MüllerShizuo AkiraNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mikaël M. Martino Kenta Maruyama Gisela A. Kuhn Takashi Satoh Osamu Takeuchi Ralph Müller Shizuo Akira Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration
description	TLR and IL-1R1 ligands are danger signals released following tissue injury and during the healing response. Here, the authors show that IL-1β signalling via IL-1R1/MyD88 inhibits the Akt/GSK-3β/β-catenin pathway in mesenchymal stem cells, which suppresses their mobilization, proliferation, and differentiation into osteoblasts, processes necessary for bone regeneration.
format	article
author	Mikaël M. Martino Kenta Maruyama Gisela A. Kuhn Takashi Satoh Osamu Takeuchi Ralph Müller Shizuo Akira
author_facet	Mikaël M. Martino Kenta Maruyama Gisela A. Kuhn Takashi Satoh Osamu Takeuchi Ralph Müller Shizuo Akira
author_sort	Mikaël M. Martino
title	Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration
title_short	Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration
title_full	Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration
title_fullStr	Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration
title_full_unstemmed	Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration
title_sort	inhibition of il-1r1/myd88 signalling promotes mesenchymal stem cell-driven tissue regeneration
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/153147c9da8341d39d1128c501422b75
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Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

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