Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer models, including aggressive CNS tumours, in a cyto...

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Autores principales: Shawn T. Beug, Caroline E. Beauregard, Cristin Healy, Tarun Sanda, Martine St-Jean, Janelle Chabot, Danielle E. Walker, Aditya Mohan, Nathalie Earl, Xueqing Lun, Donna L. Senger, Stephen M. Robbins, Peter Staeheli, Peter A. Forsyth, Tommy Alain, Eric C. LaCasse, Robert G. Korneluk
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/153f1f0b72134cffba06e3aad0670491
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https://doaj.org/article/153f1f0b72134cffba06e3aad0670491

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