Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer models, including aggressive CNS tumours, in a cyto...

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Autores principales:	Shawn T. Beug, Caroline E. Beauregard, Cristin Healy, Tarun Sanda, Martine St-Jean, Janelle Chabot, Danielle E. Walker, Aditya Mohan, Nathalie Earl, Xueqing Lun, Donna L. Senger, Stephen M. Robbins, Peter Staeheli, Peter A. Forsyth, Tommy Alain, Eric C. LaCasse, Robert G. Korneluk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/153f1f0b72134cffba06e3aad0670491
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spelling	oai:doaj.org-article:153f1f0b72134cffba06e3aad06704912021-12-02T17:01:21ZSmac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma10.1038/ncomms142782041-1723https://doaj.org/article/153f1f0b72134cffba06e3aad06704912017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14278https://doaj.org/toc/2041-1723Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer models, including aggressive CNS tumours, in a cytotoxic CD8+T-cell- and TNFα-dependent manner.Shawn T. BeugCaroline E. BeauregardCristin HealyTarun SandaMartine St-JeanJanelle ChabotDanielle E. WalkerAditya MohanNathalie EarlXueqing LunDonna L. SengerStephen M. RobbinsPeter StaeheliPeter A. ForsythTommy AlainEric C. LaCasseRobert G. KornelukNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shawn T. Beug Caroline E. Beauregard Cristin Healy Tarun Sanda Martine St-Jean Janelle Chabot Danielle E. Walker Aditya Mohan Nathalie Earl Xueqing Lun Donna L. Senger Stephen M. Robbins Peter Staeheli Peter A. Forsyth Tommy Alain Eric C. LaCasse Robert G. Korneluk Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
description	Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer models, including aggressive CNS tumours, in a cytotoxic CD8+T-cell- and TNFα-dependent manner.
format	article
author	Shawn T. Beug Caroline E. Beauregard Cristin Healy Tarun Sanda Martine St-Jean Janelle Chabot Danielle E. Walker Aditya Mohan Nathalie Earl Xueqing Lun Donna L. Senger Stephen M. Robbins Peter Staeheli Peter A. Forsyth Tommy Alain Eric C. LaCasse Robert G. Korneluk
author_facet	Shawn T. Beug Caroline E. Beauregard Cristin Healy Tarun Sanda Martine St-Jean Janelle Chabot Danielle E. Walker Aditya Mohan Nathalie Earl Xueqing Lun Donna L. Senger Stephen M. Robbins Peter Staeheli Peter A. Forsyth Tommy Alain Eric C. LaCasse Robert G. Korneluk
author_sort	Shawn T. Beug
title	Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
title_short	Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
title_full	Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
title_fullStr	Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
title_full_unstemmed	Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
title_sort	smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/153f1f0b72134cffba06e3aad0670491
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Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

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