Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer models, including aggressive CNS tumours, in a cyto...
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Autores principales: | Shawn T. Beug, Caroline E. Beauregard, Cristin Healy, Tarun Sanda, Martine St-Jean, Janelle Chabot, Danielle E. Walker, Aditya Mohan, Nathalie Earl, Xueqing Lun, Donna L. Senger, Stephen M. Robbins, Peter Staeheli, Peter A. Forsyth, Tommy Alain, Eric C. LaCasse, Robert G. Korneluk |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/153f1f0b72134cffba06e3aad0670491 |
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