Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma

Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma

Circulating tumour cells can be useful for monitoring disease progression but how they survive in the circulatory system is unclear. Here, the authors use single-cell sequencing of circulating tumour cells from multiple vascular sites in liver cancer patients and identify genes that may help the cel...

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Autores principales: Yun-Fan Sun, Liang Wu, Shi-Ping Liu, Miao-Miao Jiang, Bo Hu, Kai-Qian Zhou, Wei Guo, Yang Xu, Yu Zhong, Xiao-Rui Zhou, Ze-Fan Zhang, Geng Liu, Sheng Liu, Ying-Hong Shi, Yuan Ji, Min Du, Nan-Nan Li, Gui-Bo Li, Zhi-Kun Zhao, Xiao-Yun Huang, Li-Qin Xu, Qi-Chao Yu, David H. Peng, Shuang-Jian Qiu, Hui-Chuan Sun, Michael Dean, Xiang-Dong Wang, Wen-Yuan Chung, Ashley R. Dennison, Jian Zhou, Yong Hou, Jia Fan, Xin-Rong Yang
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/156c23ef884041eba86aff0b60e3ab05
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spelling oai:doaj.org-article:156c23ef884041eba86aff0b60e3ab052021-12-02T16:32:13ZDissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma10.1038/s41467-021-24386-02041-1723https://doaj.org/article/156c23ef884041eba86aff0b60e3ab052021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24386-0https://doaj.org/toc/2041-1723Circulating tumour cells can be useful for monitoring disease progression but how they survive in the circulatory system is unclear. Here, the authors use single-cell sequencing of circulating tumour cells from multiple vascular sites in liver cancer patients and identify genes that may help the cells survive.Yun-Fan SunLiang WuShi-Ping LiuMiao-Miao JiangBo HuKai-Qian ZhouWei GuoYang XuYu ZhongXiao-Rui ZhouZe-Fan ZhangGeng LiuSheng LiuYing-Hong ShiYuan JiMin DuNan-Nan LiGui-Bo LiZhi-Kun ZhaoXiao-Yun HuangLi-Qin XuQi-Chao YuDavid H. PengShuang-Jian QiuHui-Chuan SunMichael DeanXiang-Dong WangWen-Yuan ChungAshley R. DennisonJian ZhouYong HouJia FanXin-Rong YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yun-Fan Sun
Liang Wu
Shi-Ping Liu
Miao-Miao Jiang
Bo Hu
Kai-Qian Zhou
Wei Guo
Yang Xu
Yu Zhong
Xiao-Rui Zhou
Ze-Fan Zhang
Geng Liu
Sheng Liu
Ying-Hong Shi
Yuan Ji
Min Du
Nan-Nan Li
Gui-Bo Li
Zhi-Kun Zhao
Xiao-Yun Huang
Li-Qin Xu
Qi-Chao Yu
David H. Peng
Shuang-Jian Qiu
Hui-Chuan Sun
Michael Dean
Xiang-Dong Wang
Wen-Yuan Chung
Ashley R. Dennison
Jian Zhou
Yong Hou
Jia Fan
Xin-Rong Yang
Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma
description Circulating tumour cells can be useful for monitoring disease progression but how they survive in the circulatory system is unclear. Here, the authors use single-cell sequencing of circulating tumour cells from multiple vascular sites in liver cancer patients and identify genes that may help the cells survive.
format article
author Yun-Fan Sun
Liang Wu
Shi-Ping Liu
Miao-Miao Jiang
Bo Hu
Kai-Qian Zhou
Wei Guo
Yang Xu
Yu Zhong
Xiao-Rui Zhou
Ze-Fan Zhang
Geng Liu
Sheng Liu
Ying-Hong Shi
Yuan Ji
Min Du
Nan-Nan Li
Gui-Bo Li
Zhi-Kun Zhao
Xiao-Yun Huang
Li-Qin Xu
Qi-Chao Yu
David H. Peng
Shuang-Jian Qiu
Hui-Chuan Sun
Michael Dean
Xiang-Dong Wang
Wen-Yuan Chung
Ashley R. Dennison
Jian Zhou
Yong Hou
Jia Fan
Xin-Rong Yang
author_facet Yun-Fan Sun
Liang Wu
Shi-Ping Liu
Miao-Miao Jiang
Bo Hu
Kai-Qian Zhou
Wei Guo
Yang Xu
Yu Zhong
Xiao-Rui Zhou
Ze-Fan Zhang
Geng Liu
Sheng Liu
Ying-Hong Shi
Yuan Ji
Min Du
Nan-Nan Li
Gui-Bo Li
Zhi-Kun Zhao
Xiao-Yun Huang
Li-Qin Xu
Qi-Chao Yu
David H. Peng
Shuang-Jian Qiu
Hui-Chuan Sun
Michael Dean
Xiang-Dong Wang
Wen-Yuan Chung
Ashley R. Dennison
Jian Zhou
Yong Hou
Jia Fan
Xin-Rong Yang
author_sort Yun-Fan Sun
title Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma
title_short Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma
title_full Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma
title_fullStr Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma
title_full_unstemmed Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma
title_sort dissecting spatial heterogeneity and the immune-evasion mechanism of ctcs by single-cell rna-seq in hepatocellular carcinoma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/156c23ef884041eba86aff0b60e3ab05
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