Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

RIPK3-mediated phosphorylation of the mixed lineage kinase domain-like (MLKL) pseudokinase is thought to be the trigger for MLKL activation during necroptotic signaling. Here the authors provide evidence that the transition of human MLKL from a monomeric state to a tetramer is essential for necropto...

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Autores principales:	Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen, Brian J. Smith, Michael D. W. Griffin, Isabelle S. Lucet, Weiwen Dai, Samuel N. Young, Maria C. Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D. Cowan, Joanne M. Hildebrand, Wilhelmus J. A. Kersten, Guillaume Lessene, John Silke, Peter E. Czabotar, Andrew I. Webb, James M. Murphy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15857781bc14483aa896810340066149
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spelling	oai:doaj.org-article:15857781bc14483aa8968103400661492021-12-02T15:34:44ZConformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis10.1038/s41467-018-04714-72041-1723https://doaj.org/article/15857781bc14483aa8968103400661492018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04714-7https://doaj.org/toc/2041-1723RIPK3-mediated phosphorylation of the mixed lineage kinase domain-like (MLKL) pseudokinase is thought to be the trigger for MLKL activation during necroptotic signaling. Here the authors provide evidence that the transition of human MLKL from a monomeric state to a tetramer is essential for necroptosis signalling.Emma J. PetrieJarrod J. SandowAnnette V. JacobsenBrian J. SmithMichael D. W. GriffinIsabelle S. LucetWeiwen DaiSamuel N. YoungMaria C. TanzerAhmad WardakLung-Yu LiangAngus D. CowanJoanne M. HildebrandWilhelmus J. A. KerstenGuillaume LesseneJohn SilkePeter E. CzabotarAndrew I. WebbJames M. MurphyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emma J. Petrie Jarrod J. Sandow Annette V. Jacobsen Brian J. Smith Michael D. W. Griffin Isabelle S. Lucet Weiwen Dai Samuel N. Young Maria C. Tanzer Ahmad Wardak Lung-Yu Liang Angus D. Cowan Joanne M. Hildebrand Wilhelmus J. A. Kersten Guillaume Lessene John Silke Peter E. Czabotar Andrew I. Webb James M. Murphy Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
description	RIPK3-mediated phosphorylation of the mixed lineage kinase domain-like (MLKL) pseudokinase is thought to be the trigger for MLKL activation during necroptotic signaling. Here the authors provide evidence that the transition of human MLKL from a monomeric state to a tetramer is essential for necroptosis signalling.
format	article
author	Emma J. Petrie Jarrod J. Sandow Annette V. Jacobsen Brian J. Smith Michael D. W. Griffin Isabelle S. Lucet Weiwen Dai Samuel N. Young Maria C. Tanzer Ahmad Wardak Lung-Yu Liang Angus D. Cowan Joanne M. Hildebrand Wilhelmus J. A. Kersten Guillaume Lessene John Silke Peter E. Czabotar Andrew I. Webb James M. Murphy
author_facet	Emma J. Petrie Jarrod J. Sandow Annette V. Jacobsen Brian J. Smith Michael D. W. Griffin Isabelle S. Lucet Weiwen Dai Samuel N. Young Maria C. Tanzer Ahmad Wardak Lung-Yu Liang Angus D. Cowan Joanne M. Hildebrand Wilhelmus J. A. Kersten Guillaume Lessene John Silke Peter E. Czabotar Andrew I. Webb James M. Murphy
author_sort	Emma J. Petrie
title	Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
title_short	Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
title_full	Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
title_fullStr	Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
title_full_unstemmed	Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
title_sort	conformational switching of the pseudokinase domain promotes human mlkl tetramerization and cell death by necroptosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/15857781bc14483aa896810340066149
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Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

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