Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix

por Michael R. Oliver, Christopher R. Horne, Safal Shrestha, Jeremy R. Keown, Lung-Yu Liang, Samuel N. Young, Jarrod J. Sandow, Andrew I. Webb, David C. Goldstone, Isabelle S. Lucet, Natarajan Kannan, Peter Metcalf, James M. Murphy
Publicado 2021

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

por Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D. Cowan, Andre L. Samson, Guillaume Lessene, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy
Publicado 2021

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

por Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Wayland Yeung, Diane Coursier, Richard W. Birkinshaw, Jarrod J. Sandow, Wil I. L. Lehmann, Lung-Yu Liang, Isabelle S. Lucet, James D. Chalmers, Wayne M. Patrick, Natarajan Kannan, Emma J. Petrie, Peter E. Czabotar, James M. Murphy
Publicado 2020

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

por Sarah E. Garnish, Yanxiang Meng, Akiko Koide, Jarrod J. Sandow, Eric Denbaum, Annette V. Jacobsen, Wayland Yeung, Andre L. Samson, Christopher R. Horne, Cheree Fitzgibbon, Samuel N. Young, Phoebe P. C. Smith, Andrew I. Webb, Emma J. Petrie, Joanne M. Hildebrand, Natarajan Kannan, Peter E. Czabotar, Shohei Koide, James M. Murphy
Publicado 2021

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

por Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen, Brian J. Smith, Michael D. W. Griffin, Isabelle S. Lucet, Weiwen Dai, Samuel N. Young, Maria C. Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D. Cowan, Joanne M. Hildebrand, Wilhelmus J. A. Kersten, Guillaume Lessene, John Silke, Peter E. Czabotar, Andrew I. Webb, James M. Murphy
Publicado 2018

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

por Andre L. Samson, Ying Zhang, Niall D. Geoghegan, Xavier J. Gavin, Katherine A. Davies, Michael J. Mlodzianoski, Lachlan W. Whitehead, Daniel Frank, Sarah E. Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N. Young, Annette V. Jacobsen, Wayne Cawthorne, Emma J. Petrie, Maree C. Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Kelly L. Rogers, Guillaume Lessene, Edwin D. Hawkins, James M. Murphy
Publicado 2020

Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance

por Laura Ramos Garcia, Tencho Tenev, Richard Newman, Rachel O. Haich, Gianmaria Liccardi, Sidonie Wicky John, Alessandro Annibaldi, Lu Yu, Mercedes Pardo, Samuel N. Young, Cheree Fitzgibbon, Winnie Fernando, Naomi Guppy, Hyojin Kim, Lung-Yu Liang, Isabelle S. Lucet, Andrew Kueh, Ioannis Roxanis, Patrycja Gazinska, Martin Sims, Tomoko Smyth, George Ward, John Bertin, Allison M. Beal, Brad Geddes, Jyoti S. Choudhary, James M. Murphy, K. Aurelia Ball, Jason W. Upton, Pascal Meier
Publicado 2021

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

por Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison J. Cox, Sanae Miyake, Emma J. Petrie, Michael A. Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatti, Samuel N. Young, Cathrine Hall, Sarah E. Garnish, Jason Corbin, Michael D. Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C. Josefsson, Kristin Rigbye, Holly Anderton, James A. Rickard, Anne Tripaydonis, Julie Sheridan, Thomas S. Scerri, Victoria E. Jackson, Peter E. Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C. Allison, Marc Pellegrini, Gillian M. Tannahill, Esme C. Hatchell, Tracy A. Willson, Dina Stockwell, Carolyn A. de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K. Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M. Laxer, Alexander G. Bassuk, Benjamin W. Darbro, Maria A. Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David B. Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S. Hildebrand, Carola G. Vinuesa, Pamela McCombe, Matthew A. Brown, Benjamin T. Kile, Catriona McLean, Melanie Bahlo, Seth L. Masters, Hiroyasu Nakano, Polly J. Ferguson, James M. Murphy, Warren S. Alexander, John Silke
Publicado 2020