Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

Efficient therapeutic strategies to target mutant-p53 cancers are needed. Here, the authors demonstrate the molecular mechanism through which mutant-p53 tumours are susceptible to oxidative damage and propose a potential strategy for targeting such cancers by inhibiting the SLC7A11-glutathione axis.

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Detalles Bibliográficos
Autores principales:	David S. Liu, Cuong P. Duong, Sue Haupt, Karen G. Montgomery, Colin M. House, Walid J. Azar, Helen B. Pearson, Oliver M. Fisher, Matthew Read, Glen R. Guerra, Ygal Haupt, Carleen Cullinane, Klas G. Wiman, Lars Abrahmsen, Wayne A. Phillips, Nicholas J. Clemons
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/158fa6f4dc10458fa818d00a36bab589
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spelling	oai:doaj.org-article:158fa6f4dc10458fa818d00a36bab5892021-12-02T14:42:26ZInhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation10.1038/ncomms148442041-1723https://doaj.org/article/158fa6f4dc10458fa818d00a36bab5892017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14844https://doaj.org/toc/2041-1723Efficient therapeutic strategies to target mutant-p53 cancers are needed. Here, the authors demonstrate the molecular mechanism through which mutant-p53 tumours are susceptible to oxidative damage and propose a potential strategy for targeting such cancers by inhibiting the SLC7A11-glutathione axis.David S. LiuCuong P. DuongSue HauptKaren G. MontgomeryColin M. HouseWalid J. AzarHelen B. PearsonOliver M. FisherMatthew ReadGlen R. GuerraYgal HauptCarleen CullinaneKlas G. WimanLars AbrahmsenWayne A. PhillipsNicholas J. ClemonsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David S. Liu Cuong P. Duong Sue Haupt Karen G. Montgomery Colin M. House Walid J. Azar Helen B. Pearson Oliver M. Fisher Matthew Read Glen R. Guerra Ygal Haupt Carleen Cullinane Klas G. Wiman Lars Abrahmsen Wayne A. Phillips Nicholas J. Clemons Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
description	Efficient therapeutic strategies to target mutant-p53 cancers are needed. Here, the authors demonstrate the molecular mechanism through which mutant-p53 tumours are susceptible to oxidative damage and propose a potential strategy for targeting such cancers by inhibiting the SLC7A11-glutathione axis.
format	article
author	David S. Liu Cuong P. Duong Sue Haupt Karen G. Montgomery Colin M. House Walid J. Azar Helen B. Pearson Oliver M. Fisher Matthew Read Glen R. Guerra Ygal Haupt Carleen Cullinane Klas G. Wiman Lars Abrahmsen Wayne A. Phillips Nicholas J. Clemons
author_facet	David S. Liu Cuong P. Duong Sue Haupt Karen G. Montgomery Colin M. House Walid J. Azar Helen B. Pearson Oliver M. Fisher Matthew Read Glen R. Guerra Ygal Haupt Carleen Cullinane Klas G. Wiman Lars Abrahmsen Wayne A. Phillips Nicholas J. Clemons
author_sort	David S. Liu
title	Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
title_short	Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
title_full	Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
title_fullStr	Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
title_full_unstemmed	Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
title_sort	inhibiting the system xc−/glutathione axis selectively targets cancers with mutant-p53 accumulation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/158fa6f4dc10458fa818d00a36bab589
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Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

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