Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant <italic toggle="yes">Klebsiella pneumoniae</italic> and <italic toggle="yes">Enterobacter cloacae</italic>

Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant <italic toggle="yes">Klebsiella pneumoniae</italic> and <italic toggle="yes">Enterobacter cloacae</italic>

ABSTRACT Poor penetration through the outer membrane (OM) of Gram-negative bacteria is a major barrier of antibiotic development. While β-lactam antibiotics are commonly used against Klebsiella pneumoniae and Enterobacter cloacae, there are limited data on OM permeability especially in K. pneumoniae...

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Main Authors: Tae Hwan Kim, Xun Tao, Bartolome Moya, Yuanyuan Jiao, Kari B. Basso, Jieqiang Zhou, Yinzhi Lang, Dhruvitkumar S. Sutaria, Alexandre P. Zavascki, Afonso L. Barth, Stephanie M. Reeve, Herbert P. Schweizer, Deanna Deveson Lucas, John D. Boyce, Robert A. Bonomo, Richard E. Lee, Beom Soo Shin, Arnold Louie, George L. Drusano, Jürgen B. Bulitta
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
Enterobacter cloacae
Klebsiella pneumoniae
LC-MS/MS
beta-lactams
carbapenem resistance
carbapenems
Microbiology
QR1-502
Online Access:https://doaj.org/article/15920c889cbe439dba2992e6e5cf4623
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https://doaj.org/article/15920c889cbe439dba2992e6e5cf4623

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