Immunomodulatory Nanoparticles Mitigate Macrophage Inflammation via Inhibition of PAMP Interactions and Lactate-Mediated Functional Reprogramming of NF-κB and p38 MAPK

Immunomodulatory Nanoparticles Mitigate Macrophage Inflammation via Inhibition of PAMP Interactions and Lactate-Mediated Functional Reprogramming of NF-κB and p38 MAPK

Inflammation is a key homeostatic process involved in the body’s response to a multitude of disease states including infection, autoimmune disorders, cancer, and other chronic conditions. When the initiating event is poorly controlled, severe inflammation and globally dysregulated immune responses c...

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Autores principales: Jackline Joy Martín Lasola, Andrea L. Cottingham, Brianna L. Scotland, Nhu Truong, Charles C. Hong, Paul Shapiro, Ryan M. Pearson
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
inflammation
innate immunity
macrophages
Toll-like receptors
TLR
NF-κB
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/1592704ca67e4380840c5bbd9144f8b6
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https://doaj.org/article/1592704ca67e4380840c5bbd9144f8b6

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