Improved pyrrolysine biosynthesis through phage assisted non-continuous directed evolution of the complete pathway

Pyrrolysine (Pyl) exists in nature as the 22nd proteinogenic amino acid, but studies of Pyl have been hindered by the difficulty and inefficiency of both its chemical and biological syntheses. Here, the authors developed an improved PANCE approach to evolve the pylBCD pathway for increased productio...

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Autores principales: Joanne M. L. Ho, Corwin A. Miller, Kathryn A. Smith, Jacob R. Mattia, Matthew R. Bennett
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/15a65cff8dc74dde894fa14065c7385b
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