Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas

Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas

Abstract Up to 86% of uterine leiomyomas harbour somatic mutations in mediator complex subunit 12 (MED12). These mutations have been associated with conventional histology, smaller tumour size, and larger number of tumours within the uterus. Prior studies, with limited sample sizes, have failed to d...

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Main Authors: Hanna-Riikka Heinonen, Annukka Pasanen, Oskari Heikinheimo, Tomas Tanskanen, Kimmo Palin, Jaana Tolvanen, Pia Vahteristo, Jari Sjöberg, Esa Pitkänen, Ralf Bützow, Netta Mäkinen, Lauri A. Aaltonen
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/15a7fd008b7b42a49d3e827b391c4772
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https://doaj.org/article/15a7fd008b7b42a49d3e827b391c4772

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