Establishment of multiplex RT-PCR to detect fusion genes for the diagnosis of Ewing sarcoma

Establishment of multiplex RT-PCR to detect fusion genes for the diagnosis of Ewing sarcoma

Abstract Background Detection of the tumor-specific EWSR1/FUS-ETS fusion gene is essential to diagnose Ewing sarcoma. Reverse transcription–polymerase chain reaction (RT–PCR) and fluorescence in situ hybridization are commonly used to detect the fusion gene, and assays using next-generation sequenci...

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Autores principales: Hitomi Ueno-Yokohata, Hajime Okita, Keiko Nakasato, Chikako Kiyotani, Motohiro Kato, Kimikazu Matsumoto, Nobutaka Kiyokawa, Atsuko Nakazawa, Takako Yoshioka
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Ewing sarcoma
Multiplex RT–PCR
Genetic diagnosis
Fusion gene
EWSR1
Transcription factor
Pathology
RB1-214
Acceso en línea:https://doaj.org/article/15b950b301c143b0be4a11442dd56f90
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https://doaj.org/article/15b950b301c143b0be4a11442dd56f90

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