Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding

Protein S-sulfenylation is a posttranslational modification that can act as a sensor of redox oxidative stress. Here the authors show that, following mechanical unfolding, sulfenic acid drives disulfide bond reformation and guides non-enzymatic oxidative folding.

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Autores principales:	Amy E. M. Beedle, Steven Lynham, Sergi Garcia-Manyes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15bb57049a77463cbe99c276049de68e
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spelling	oai:doaj.org-article:15bb57049a77463cbe99c276049de68e2021-12-02T17:32:53ZProtein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding10.1038/ncomms124902041-1723https://doaj.org/article/15bb57049a77463cbe99c276049de68e2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12490https://doaj.org/toc/2041-1723Protein S-sulfenylation is a posttranslational modification that can act as a sensor of redox oxidative stress. Here the authors show that, following mechanical unfolding, sulfenic acid drives disulfide bond reformation and guides non-enzymatic oxidative folding.Amy E. M. BeedleSteven LynhamSergi Garcia-ManyesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy E. M. Beedle Steven Lynham Sergi Garcia-Manyes Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding
description	Protein S-sulfenylation is a posttranslational modification that can act as a sensor of redox oxidative stress. Here the authors show that, following mechanical unfolding, sulfenic acid drives disulfide bond reformation and guides non-enzymatic oxidative folding.
format	article
author	Amy E. M. Beedle Steven Lynham Sergi Garcia-Manyes
author_facet	Amy E. M. Beedle Steven Lynham Sergi Garcia-Manyes
author_sort	Amy E. M. Beedle
title	Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding
title_short	Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding
title_full	Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding
title_fullStr	Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding
title_full_unstemmed	Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding
title_sort	protein s-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/15bb57049a77463cbe99c276049de68e
work_keys_str_mv	AT amyembeedle proteinssulfenylationisafleetingmolecularswitchthatregulatesnonenzymaticoxidativefolding AT stevenlynham proteinssulfenylationisafleetingmolecularswitchthatregulatesnonenzymaticoxidativefolding AT sergigarciamanyes proteinssulfenylationisafleetingmolecularswitchthatregulatesnonenzymaticoxidativefolding
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Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding

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