Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons

Chloride regulation is important for setting GABAergic reversal potential, though tools to manipulate chloride levels are limited. Here, the authors combine Archaerhodopsin with a chloride channel opsin to generate an optogenetic chloride extrusion strategy, ‘Cl-out’, which they demonstrate in hippo...

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Autores principales:	Hannah Alfonsa, Jeremy H. Lakey, Robert N. Lightowlers, Andrew J. Trevelyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15f33b2623ff4087924ad2c757c8f991
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spelling	oai:doaj.org-article:15f33b2623ff4087924ad2c757c8f9912021-12-02T17:31:20ZCl-out is a novel cooperative optogenetic tool for extruding chloride from neurons10.1038/ncomms134952041-1723https://doaj.org/article/15f33b2623ff4087924ad2c757c8f9912016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13495https://doaj.org/toc/2041-1723Chloride regulation is important for setting GABAergic reversal potential, though tools to manipulate chloride levels are limited. Here, the authors combine Archaerhodopsin with a chloride channel opsin to generate an optogenetic chloride extrusion strategy, ‘Cl-out’, which they demonstrate in hippocampal slices.Hannah AlfonsaJeremy H. LakeyRobert N. LightowlersAndrew J. TrevelyanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hannah Alfonsa Jeremy H. Lakey Robert N. Lightowlers Andrew J. Trevelyan Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons
description	Chloride regulation is important for setting GABAergic reversal potential, though tools to manipulate chloride levels are limited. Here, the authors combine Archaerhodopsin with a chloride channel opsin to generate an optogenetic chloride extrusion strategy, ‘Cl-out’, which they demonstrate in hippocampal slices.
format	article
author	Hannah Alfonsa Jeremy H. Lakey Robert N. Lightowlers Andrew J. Trevelyan
author_facet	Hannah Alfonsa Jeremy H. Lakey Robert N. Lightowlers Andrew J. Trevelyan
author_sort	Hannah Alfonsa
title	Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons
title_short	Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons
title_full	Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons
title_fullStr	Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons
title_full_unstemmed	Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons
title_sort	cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/15f33b2623ff4087924ad2c757c8f991
work_keys_str_mv	AT hannahalfonsa cloutisanovelcooperativeoptogenetictoolforextrudingchloridefromneurons AT jeremyhlakey cloutisanovelcooperativeoptogenetictoolforextrudingchloridefromneurons AT robertnlightowlers cloutisanovelcooperativeoptogenetictoolforextrudingchloridefromneurons AT andrewjtrevelyan cloutisanovelcooperativeoptogenetictoolforextrudingchloridefromneurons
_version_	1718380596621737984

Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons

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