Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells.

CK2 is a pleiotropic protein kinase, which regulates many survival pathways and plays a global anti-apoptotic function. It is highly expressed in tumor cells, and is presently considered a promising therapeutic target. Among the many inhibitors available for this kinase, the recently developed CX-49...

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Autores principales: Sofia Zanin, Christian Borgo, Cristina Girardi, Sean E O'Brien, Yoshihiko Miyata, Lorenzo A Pinna, Arianna Donella-Deana, Maria Ruzzene
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/1628c93d81e54239a1197f03df0b6790
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