Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

Production of reactive oxygen species is an ancient antimicrobial mechanism, but its role in antiviral defense in mammals is unclear. Here, To et al. show that virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogen...

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Autores principales:	Eunice E. To, Ross Vlahos, Raymond Luong, Michelle L. Halls, Patrick C. Reading, Paul T. King, Christopher Chan, Grant R. Drummond, Christopher G. Sobey, Brad R. S. Broughton, Malcolm R. Starkey, Renee van der Sluis, Sharon R. Lewin, Steven Bozinovski, Luke A. J. O’Neill, Tim Quach, Christopher J. H. Porter, Doug A. Brooks, John J. O’Leary, Stavros Selemidis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1631134d108f482a9e7cb5b0a4cfdc77
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spelling	oai:doaj.org-article:1631134d108f482a9e7cb5b0a4cfdc772021-12-02T10:47:59ZEndosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy10.1038/s41467-017-00057-x2041-1723https://doaj.org/article/1631134d108f482a9e7cb5b0a4cfdc772017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00057-xhttps://doaj.org/toc/2041-1723Production of reactive oxygen species is an ancient antimicrobial mechanism, but its role in antiviral defense in mammals is unclear. Here, To et al. show that virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogenicity.Eunice E. ToRoss VlahosRaymond LuongMichelle L. HallsPatrick C. ReadingPaul T. KingChristopher ChanGrant R. DrummondChristopher G. SobeyBrad R. S. BroughtonMalcolm R. StarkeyRenee van der SluisSharon R. LewinSteven BozinovskiLuke A. J. O’NeillTim QuachChristopher J. H. PorterDoug A. BrooksJohn J. O’LearyStavros SelemidisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eunice E. To Ross Vlahos Raymond Luong Michelle L. Halls Patrick C. Reading Paul T. King Christopher Chan Grant R. Drummond Christopher G. Sobey Brad R. S. Broughton Malcolm R. Starkey Renee van der Sluis Sharon R. Lewin Steven Bozinovski Luke A. J. O’Neill Tim Quach Christopher J. H. Porter Doug A. Brooks John J. O’Leary Stavros Selemidis Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
description	Production of reactive oxygen species is an ancient antimicrobial mechanism, but its role in antiviral defense in mammals is unclear. Here, To et al. show that virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogenicity.
format	article
author	Eunice E. To Ross Vlahos Raymond Luong Michelle L. Halls Patrick C. Reading Paul T. King Christopher Chan Grant R. Drummond Christopher G. Sobey Brad R. S. Broughton Malcolm R. Starkey Renee van der Sluis Sharon R. Lewin Steven Bozinovski Luke A. J. O’Neill Tim Quach Christopher J. H. Porter Doug A. Brooks John J. O’Leary Stavros Selemidis
author_facet	Eunice E. To Ross Vlahos Raymond Luong Michelle L. Halls Patrick C. Reading Paul T. King Christopher Chan Grant R. Drummond Christopher G. Sobey Brad R. S. Broughton Malcolm R. Starkey Renee van der Sluis Sharon R. Lewin Steven Bozinovski Luke A. J. O’Neill Tim Quach Christopher J. H. Porter Doug A. Brooks John J. O’Leary Stavros Selemidis
author_sort	Eunice E. To
title	Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
title_short	Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
title_full	Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
title_fullStr	Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
title_full_unstemmed	Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
title_sort	endosomal nox2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1631134d108f482a9e7cb5b0a4cfdc77
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Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

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