A petascale automated imaging pipeline for mapping neuronal circuits with high-throughput transmission electron microscopy

A petascale automated imaging pipeline for mapping neuronal circuits with high-throughput transmission electron microscopy

Electron microscopy (EM) is the gold standard for biological ultrastructure but acquisition speed is slow, making it unsuitable for large volumes. Here the authors present a parallel imaging pipeline for continuous autonomous imaging with six transmission EMs to image 1 mm3 of mouse cortex in less t...

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Bibliographic Details
Main Authors: Wenjing Yin, Derrick Brittain, Jay Borseth, Marie E. Scott, Derric Williams, Jedediah Perkins, Christopher S. Own, Matthew Murfitt, Russel M. Torres, Daniel Kapner, Gayathri Mahalingam, Adam Bleckert, Daniel Castelli, David Reid, Wei-Chung Allen Lee, Brett J. Graham, Marc Takeno, Daniel J. Bumbarger, Colin Farrell, R. Clay Reid, Nuno Macarico da Costa
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/1636c301c307427c8f6136be5b12c53a
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https://doaj.org/article/1636c301c307427c8f6136be5b12c53a

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