XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis

Hepatocyte 12-hour rhythms have a role in cellular stress and metabolic functions. Here, the authors demonstrate disrupting the 12-hour clock through deletion of XBP1 is associated with the development of NAFLD as well as disruption of phospholipid composition and the maintenance of lipid homeostasi...

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Autores principales:	Huan Meng, Naomi M. Gonzales, David M. Lonard, Nagireddy Putluri, Bokai Zhu, Clifford C. Dacso, Brian York, Bert W. O’Malley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/163c3b3fcdb943638dd992aefa6a597d
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spelling	oai:doaj.org-article:163c3b3fcdb943638dd992aefa6a597d2021-12-02T17:31:23ZXBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis10.1038/s41467-020-20028-z2041-1723https://doaj.org/article/163c3b3fcdb943638dd992aefa6a597d2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20028-zhttps://doaj.org/toc/2041-1723Hepatocyte 12-hour rhythms have a role in cellular stress and metabolic functions. Here, the authors demonstrate disrupting the 12-hour clock through deletion of XBP1 is associated with the development of NAFLD as well as disruption of phospholipid composition and the maintenance of lipid homeostasis.Huan MengNaomi M. GonzalesDavid M. LonardNagireddy PutluriBokai ZhuClifford C. DacsoBrian YorkBert W. O’MalleyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huan Meng Naomi M. Gonzales David M. Lonard Nagireddy Putluri Bokai Zhu Clifford C. Dacso Brian York Bert W. O’Malley XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
description	Hepatocyte 12-hour rhythms have a role in cellular stress and metabolic functions. Here, the authors demonstrate disrupting the 12-hour clock through deletion of XBP1 is associated with the development of NAFLD as well as disruption of phospholipid composition and the maintenance of lipid homeostasis.
format	article
author	Huan Meng Naomi M. Gonzales David M. Lonard Nagireddy Putluri Bokai Zhu Clifford C. Dacso Brian York Bert W. O’Malley
author_facet	Huan Meng Naomi M. Gonzales David M. Lonard Nagireddy Putluri Bokai Zhu Clifford C. Dacso Brian York Bert W. O’Malley
author_sort	Huan Meng
title	XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
title_short	XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
title_full	XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
title_fullStr	XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
title_full_unstemmed	XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
title_sort	xbp1 links the 12-hour clock to nafld and regulation of membrane fluidity and lipid homeostasis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/163c3b3fcdb943638dd992aefa6a597d
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XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis

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