FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs

Abstract Focal adhesion kinase (FAK) localizes to focal adhesions and is overexpressed in many cancers. FAK can also translocate to the nucleus, where it binds to, and regulates, several transcription factors, including MBD2, p53 and IL-33, to control gene expression by unknown mechanisms. We have u...

Full description

Saved in:
Bibliographic Details
Main Authors: Billie G. C. Griffith, Rosanna Upstill-Goddard, Holly Brunton, Graeme R. Grimes, Andrew V. Biankin, Bryan Serrels, Adam Byron, Margaret C. Frame
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/164998aec79f4674b257ec55ae3e2b20
Tags: Add Tag
No Tags, Be the first to tag this record!