Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy

Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy

Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range unce...

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Autores principales: Jan Hofmaier, Franziska Walter, Indrawati Hadi, Maya Rottler, Rieke von Bestenbostel, George Dedes, Katia Parodi, Maximilian Niyazi, Claus Belka, Florian Kamp
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Proton therapy
Range uncertainty
Setup uncertainty
Inter-observer variability
Sensitivity analysis
Medical physics. Medical radiology. Nuclear medicine
R895-920
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/1666d4270de8460cb26247437d4a22a9
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https://doaj.org/article/1666d4270de8460cb26247437d4a22a9

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