Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy

Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range unce...

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Autores principales:	Jan Hofmaier, Franziska Walter, Indrawati Hadi, Maya Rottler, Rieke von Bestenbostel, George Dedes, Katia Parodi, Maximilian Niyazi, Claus Belka, Florian Kamp
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Proton therapy Range uncertainty Setup uncertainty Inter-observer variability Sensitivity analysis Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1666d4270de8460cb26247437d4a22a9
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id	oai:doaj.org-article:1666d4270de8460cb26247437d4a22a9
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spelling	oai:doaj.org-article:1666d4270de8460cb26247437d4a22a92021-12-04T04:35:22ZCombining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy2405-631610.1016/j.phro.2021.11.005https://doaj.org/article/1666d4270de8460cb26247437d4a22a92021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405631621000695https://doaj.org/toc/2405-6316Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range uncertainty in a variance-based sensitivity analysis (SA). For ten patients with skull base meningioma, the mean calculation time to perform the SA including 1.6 × 104 dose recalculations was 59 min. For two patients in this dataset, IOV had a relevant impact on the estimated CTV D95% uncertainty.Jan HofmaierFranziska WalterIndrawati HadiMaya RottlerRieke von BestenbostelGeorge DedesKatia ParodiMaximilian NiyaziClaus BelkaFlorian KampElsevierarticleProton therapyRange uncertaintySetup uncertaintyInter-observer variabilitySensitivity analysisMedical physics. Medical radiology. Nuclear medicineR895-920Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENPhysics and Imaging in Radiation Oncology, Vol 20, Iss , Pp 117-120 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Proton therapy Range uncertainty Setup uncertainty Inter-observer variability Sensitivity analysis Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Proton therapy Range uncertainty Setup uncertainty Inter-observer variability Sensitivity analysis Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jan Hofmaier Franziska Walter Indrawati Hadi Maya Rottler Rieke von Bestenbostel George Dedes Katia Parodi Maximilian Niyazi Claus Belka Florian Kamp Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy
description	Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range uncertainty in a variance-based sensitivity analysis (SA). For ten patients with skull base meningioma, the mean calculation time to perform the SA including 1.6 × 104 dose recalculations was 59 min. For two patients in this dataset, IOV had a relevant impact on the estimated CTV D95% uncertainty.
format	article
author	Jan Hofmaier Franziska Walter Indrawati Hadi Maya Rottler Rieke von Bestenbostel George Dedes Katia Parodi Maximilian Niyazi Claus Belka Florian Kamp
author_facet	Jan Hofmaier Franziska Walter Indrawati Hadi Maya Rottler Rieke von Bestenbostel George Dedes Katia Parodi Maximilian Niyazi Claus Belka Florian Kamp
author_sort	Jan Hofmaier
title	Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy
title_short	Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy
title_full	Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy
title_fullStr	Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy
title_full_unstemmed	Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy
title_sort	combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1666d4270de8460cb26247437d4a22a9
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Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy

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