Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis

Knee osteoarthritis (KOA) is a common disease with no specific treatment. Icariin (ICA) is considered an agent for KOA. This study aimed to confirm the pain-related neuromodulation mechanisms of ICA on KOA. Three experiments were designed: (1) verifying the therapeutic effects of ICA in vivo and in...

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Autores principales:	Xihai Li, Yunteng Xu, Hui Li, Liangliang Jia, Jie Wang, Shengxiang Liang, Aoling Cai, Xue Tan, Lili Wang, Xiaoning Wang, Yanfeng Huang, Enxiang Tao, Hongzhi Ye, Tetsuya Asakawa
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Icariin Knee osteoarthritis Neuropeptides Functional magnetic resonance imaging Virus retrograde tracing, pain-related genes Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/16868108e4de4c479a03727408b2d7dd
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spelling	oai:doaj.org-article:16868108e4de4c479a03727408b2d7dd2021-11-14T04:28:56ZVerification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis0753-332210.1016/j.biopha.2021.112259https://doaj.org/article/16868108e4de4c479a03727408b2d7dd2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S075333222101043Xhttps://doaj.org/toc/0753-3322Knee osteoarthritis (KOA) is a common disease with no specific treatment. Icariin (ICA) is considered an agent for KOA. This study aimed to confirm the pain-related neuromodulation mechanisms of ICA on KOA. Three experiments were designed: (1) verifying the therapeutic effects of ICA in vivo and in vitro, (2) exploring the potential pain-related neuromodulation pathways involved in ICA treatment by functional magnetic resonance imaging (fMRI) and virus retrograde tracing (VRT) and (3) confirming the pain-related targets by tandem mass tag (TMT)-based quantitative proteomics and bioinformatic analyses. Experiment 1 verified the efficacy of ICA in OA animal and cell models. Experiment 2 found a series of brain regions associated with KOA reversed by ICA treatment, indicating that a pain-related hypothalamic-mediated neuromodulation pathway and an endocannabinoid (EC)-related pathway contribute to ICA mechanisms. Experiment 3 explored and confirmed four pain-related genes involved in KOA and ICA treatment. We confirmed the key role of pain-related neuromodulation mechanisms in ICA treatment associated with its analgesic effect. Our findings contribute to considering ICA as a novel therapy for KOA.Xihai LiYunteng XuHui LiLiangliang JiaJie WangShengxiang LiangAoling CaiXue TanLili WangXiaoning WangYanfeng HuangEnxiang TaoHongzhi YeTetsuya AsakawaElsevierarticleIcariinKnee osteoarthritisNeuropeptidesFunctional magnetic resonance imagingVirus retrograde tracing, pain-related genesTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112259- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Icariin Knee osteoarthritis Neuropeptides Functional magnetic resonance imaging Virus retrograde tracing, pain-related genes Therapeutics. Pharmacology RM1-950
spellingShingle	Icariin Knee osteoarthritis Neuropeptides Functional magnetic resonance imaging Virus retrograde tracing, pain-related genes Therapeutics. Pharmacology RM1-950 Xihai Li Yunteng Xu Hui Li Liangliang Jia Jie Wang Shengxiang Liang Aoling Cai Xue Tan Lili Wang Xiaoning Wang Yanfeng Huang Enxiang Tao Hongzhi Ye Tetsuya Asakawa Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis
description	Knee osteoarthritis (KOA) is a common disease with no specific treatment. Icariin (ICA) is considered an agent for KOA. This study aimed to confirm the pain-related neuromodulation mechanisms of ICA on KOA. Three experiments were designed: (1) verifying the therapeutic effects of ICA in vivo and in vitro, (2) exploring the potential pain-related neuromodulation pathways involved in ICA treatment by functional magnetic resonance imaging (fMRI) and virus retrograde tracing (VRT) and (3) confirming the pain-related targets by tandem mass tag (TMT)-based quantitative proteomics and bioinformatic analyses. Experiment 1 verified the efficacy of ICA in OA animal and cell models. Experiment 2 found a series of brain regions associated with KOA reversed by ICA treatment, indicating that a pain-related hypothalamic-mediated neuromodulation pathway and an endocannabinoid (EC)-related pathway contribute to ICA mechanisms. Experiment 3 explored and confirmed four pain-related genes involved in KOA and ICA treatment. We confirmed the key role of pain-related neuromodulation mechanisms in ICA treatment associated with its analgesic effect. Our findings contribute to considering ICA as a novel therapy for KOA.
format	article
author	Xihai Li Yunteng Xu Hui Li Liangliang Jia Jie Wang Shengxiang Liang Aoling Cai Xue Tan Lili Wang Xiaoning Wang Yanfeng Huang Enxiang Tao Hongzhi Ye Tetsuya Asakawa
author_facet	Xihai Li Yunteng Xu Hui Li Liangliang Jia Jie Wang Shengxiang Liang Aoling Cai Xue Tan Lili Wang Xiaoning Wang Yanfeng Huang Enxiang Tao Hongzhi Ye Tetsuya Asakawa
author_sort	Xihai Li
title	Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis
title_short	Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis
title_full	Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis
title_fullStr	Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis
title_full_unstemmed	Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis
title_sort	verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/16868108e4de4c479a03727408b2d7dd
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Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis

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