Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
Microglia can clear amyloid plaques in Alzheimer’s disease. Here, the authors show that specific isoforms of the phospholipid forming APOE lipoproteins activate microglia in pre-clinical mouse models of Alzheimer’s disease.
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Auteurs principaux: | Nicholas F. Fitz, Kyong Nyon Nam, Cody M. Wolfe, Florent Letronne, Brittany E. Playso, Bistra E. Iordanova, Takashi D. Y. Kozai, Richard J. Biedrzycki, Valerian E. Kagan, Yulia Y. Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamova |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
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Accès en ligne: | https://doaj.org/article/16908adbabbe48e7b4e51149f560d6dc |
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