Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

Microglia can clear amyloid plaques in Alzheimer’s disease. Here, the authors show that specific isoforms of the phospholipid forming APOE lipoproteins activate microglia in pre-clinical mouse models of Alzheimer’s disease.

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Détails bibliographiques
Auteurs principaux:	Nicholas F. Fitz, Kyong Nyon Nam, Cody M. Wolfe, Florent Letronne, Brittany E. Playso, Bistra E. Iordanova, Takashi D. Y. Kozai, Richard J. Biedrzycki, Valerian E. Kagan, Yulia Y. Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamova
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/16908adbabbe48e7b4e51149f560d6dc
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Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

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