The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD

The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD

The important tuberculosis drug pyrazinamide (PZA) is converted to its active form pyrazinoic acid (POA) in Mycobacterium tuberculosis (Mtb). Here the authors identify the pantothenate biosynthesis pathway enzyme aspartate decarboxylase (PanD) as the target of PZA and determine the POA bound Mtb Pan...

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Autores principales: Qingan Sun, Xiaojun Li, Lisa M. Perez, Wanliang Shi, Ying Zhang, James C. Sacchettini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/169473de3b71419aa5a136c2eae1f753
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spelling oai:doaj.org-article:169473de3b71419aa5a136c2eae1f7532021-12-02T17:33:14ZThe molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD10.1038/s41467-019-14238-32041-1723https://doaj.org/article/169473de3b71419aa5a136c2eae1f7532020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14238-3https://doaj.org/toc/2041-1723The important tuberculosis drug pyrazinamide (PZA) is converted to its active form pyrazinoic acid (POA) in Mycobacterium tuberculosis (Mtb). Here the authors identify the pantothenate biosynthesis pathway enzyme aspartate decarboxylase (PanD) as the target of PZA and determine the POA bound Mtb PanD crystal structure.Qingan SunXiaojun LiLisa M. PerezWanliang ShiYing ZhangJames C. SacchettiniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qingan Sun
Xiaojun Li
Lisa M. Perez
Wanliang Shi
Ying Zhang
James C. Sacchettini
The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD
description The important tuberculosis drug pyrazinamide (PZA) is converted to its active form pyrazinoic acid (POA) in Mycobacterium tuberculosis (Mtb). Here the authors identify the pantothenate biosynthesis pathway enzyme aspartate decarboxylase (PanD) as the target of PZA and determine the POA bound Mtb PanD crystal structure.
format article
author Qingan Sun
Xiaojun Li
Lisa M. Perez
Wanliang Shi
Ying Zhang
James C. Sacchettini
author_facet Qingan Sun
Xiaojun Li
Lisa M. Perez
Wanliang Shi
Ying Zhang
James C. Sacchettini
author_sort Qingan Sun
title The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD
title_short The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD
title_full The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD
title_fullStr The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD
title_full_unstemmed The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD
title_sort molecular basis of pyrazinamide activity on mycobacterium tuberculosis pand
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/169473de3b71419aa5a136c2eae1f753
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