Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase

Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase

Here the authors combine next generation sequencing on plasma from participants of the ADVANCE clinical trial with virological and follow-up data to investigate the impact of pre-treatment drug resistance (PDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) on the efficacy of second-gen...

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Main Authors: Mark J. Siedner, Michelle A. Moorhouse, Bryony Simmons, Tulio de Oliveira, Richard Lessells, Jennifer Giandhari, Stephen A. Kemp, Benjamin Chimukangara, Godspower Akpomiemie, Celicia M. Serenata, Willem D. F. Venter, Andrew Hill, Ravindra K. Gupta
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/1698782bd5904ceaa2191d4ec77b5aff
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https://doaj.org/article/1698782bd5904ceaa2191d4ec77b5aff

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