Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase
Here the authors combine next generation sequencing on plasma from participants of the ADVANCE clinical trial with virological and follow-up data to investigate the impact of pre-treatment drug resistance (PDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) on the efficacy of second-gen...
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Nature Portfolio
2020
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oai:doaj.org-article:1698782bd5904ceaa2191d4ec77b5aff2021-12-02T15:39:13ZReduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase10.1038/s41467-020-19801-x2041-1723https://doaj.org/article/1698782bd5904ceaa2191d4ec77b5aff2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19801-xhttps://doaj.org/toc/2041-1723Here the authors combine next generation sequencing on plasma from participants of the ADVANCE clinical trial with virological and follow-up data to investigate the impact of pre-treatment drug resistance (PDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) on the efficacy of second-generation integrase inhibitors and find an association between NNRTI resistance prior to treatment and long-term treatment.Mark J. SiednerMichelle A. MoorhouseBryony SimmonsTulio de OliveiraRichard LessellsJennifer GiandhariStephen A. KempBenjamin ChimukangaraGodspower AkpomiemieCelicia M. SerenataWillem D. F. VenterAndrew HillRavindra K. GuptaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mark J. Siedner Michelle A. Moorhouse Bryony Simmons Tulio de Oliveira Richard Lessells Jennifer Giandhari Stephen A. Kemp Benjamin Chimukangara Godspower Akpomiemie Celicia M. Serenata Willem D. F. Venter Andrew Hill Ravindra K. Gupta Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase |
| description |
Here the authors combine next generation sequencing on plasma from participants of the ADVANCE clinical trial with virological and follow-up data to investigate the impact of pre-treatment drug resistance (PDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) on the efficacy of second-generation integrase inhibitors and find an association between NNRTI resistance prior to treatment and long-term treatment. |
| format |
article |
| author |
Mark J. Siedner Michelle A. Moorhouse Bryony Simmons Tulio de Oliveira Richard Lessells Jennifer Giandhari Stephen A. Kemp Benjamin Chimukangara Godspower Akpomiemie Celicia M. Serenata Willem D. F. Venter Andrew Hill Ravindra K. Gupta |
| author_facet |
Mark J. Siedner Michelle A. Moorhouse Bryony Simmons Tulio de Oliveira Richard Lessells Jennifer Giandhari Stephen A. Kemp Benjamin Chimukangara Godspower Akpomiemie Celicia M. Serenata Willem D. F. Venter Andrew Hill Ravindra K. Gupta |
| author_sort |
Mark J. Siedner |
| title |
Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase |
| title_short |
Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase |
| title_full |
Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase |
| title_fullStr |
Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase |
| title_full_unstemmed |
Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase |
| title_sort |
reduced efficacy of hiv-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/1698782bd5904ceaa2191d4ec77b5aff |
| work_keys_str_mv |
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