A distinct assembly pathway of the human 39S late pre-mitoribosome

Assembly of the mitoribosome requires assistance from numerous specialized factors. Here, structures of the human 39S late assembly intermediates identify several assembly factors which keep the 16S rRNA in immature conformations, and reveal deacylated tRNA in the ribosomal E-site, suggesting a role...

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Autores principales:	Jingdong Cheng, Otto Berninghausen, Roland Beckmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/16a03bc0d75a4090929488223c675e99
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id	oai:doaj.org-article:16a03bc0d75a4090929488223c675e99
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spelling	oai:doaj.org-article:16a03bc0d75a4090929488223c675e992021-12-02T16:31:49ZA distinct assembly pathway of the human 39S late pre-mitoribosome10.1038/s41467-021-24818-x2041-1723https://doaj.org/article/16a03bc0d75a4090929488223c675e992021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24818-xhttps://doaj.org/toc/2041-1723Assembly of the mitoribosome requires assistance from numerous specialized factors. Here, structures of the human 39S late assembly intermediates identify several assembly factors which keep the 16S rRNA in immature conformations, and reveal deacylated tRNA in the ribosomal E-site, suggesting a role in 39S assembly.Jingdong ChengOtto BerninghausenRoland BeckmannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingdong Cheng Otto Berninghausen Roland Beckmann A distinct assembly pathway of the human 39S late pre-mitoribosome
description	Assembly of the mitoribosome requires assistance from numerous specialized factors. Here, structures of the human 39S late assembly intermediates identify several assembly factors which keep the 16S rRNA in immature conformations, and reveal deacylated tRNA in the ribosomal E-site, suggesting a role in 39S assembly.
format	article
author	Jingdong Cheng Otto Berninghausen Roland Beckmann
author_facet	Jingdong Cheng Otto Berninghausen Roland Beckmann
author_sort	Jingdong Cheng
title	A distinct assembly pathway of the human 39S late pre-mitoribosome
title_short	A distinct assembly pathway of the human 39S late pre-mitoribosome
title_full	A distinct assembly pathway of the human 39S late pre-mitoribosome
title_fullStr	A distinct assembly pathway of the human 39S late pre-mitoribosome
title_full_unstemmed	A distinct assembly pathway of the human 39S late pre-mitoribosome
title_sort	distinct assembly pathway of the human 39s late pre-mitoribosome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16a03bc0d75a4090929488223c675e99
work_keys_str_mv	AT jingdongcheng adistinctassemblypathwayofthehuman39slatepremitoribosome AT ottoberninghausen adistinctassemblypathwayofthehuman39slatepremitoribosome AT rolandbeckmann adistinctassemblypathwayofthehuman39slatepremitoribosome AT jingdongcheng distinctassemblypathwayofthehuman39slatepremitoribosome AT ottoberninghausen distinctassemblypathwayofthehuman39slatepremitoribosome AT rolandbeckmann distinctassemblypathwayofthehuman39slatepremitoribosome
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A distinct assembly pathway of the human 39S late pre-mitoribosome

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