Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment

How heterogeneities arise in stem cell populations remains unclear. Here, Glen et al. find that in ESC colonies cell cycle asynchronies modulate gap junctions, causing variation in intracellular signalling molecule diffusion between cells, and ultimately in spatial heterogeneity in differentiation.

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Detalles Bibliográficos
Autores principales: Chad M. Glen, Todd C. McDevitt, Melissa L. Kemp
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/16b2365f5be44ed684389cdc6a17a6c0
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