Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment

How heterogeneities arise in stem cell populations remains unclear. Here, Glen et al. find that in ESC colonies cell cycle asynchronies modulate gap junctions, causing variation in intracellular signalling molecule diffusion between cells, and ultimately in spatial heterogeneity in differentiation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Chad M. Glen, Todd C. McDevitt, Melissa L. Kemp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/16b2365f5be44ed684389cdc6a17a6c0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16b2365f5be44ed684389cdc6a17a6c0
record_format	dspace
spelling	oai:doaj.org-article:16b2365f5be44ed684389cdc6a17a6c02021-12-02T14:39:47ZDynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment10.1038/s41467-018-06693-12041-1723https://doaj.org/article/16b2365f5be44ed684389cdc6a17a6c02018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06693-1https://doaj.org/toc/2041-1723How heterogeneities arise in stem cell populations remains unclear. Here, Glen et al. find that in ESC colonies cell cycle asynchronies modulate gap junctions, causing variation in intracellular signalling molecule diffusion between cells, and ultimately in spatial heterogeneity in differentiation.Chad M. GlenTodd C. McDevittMelissa L. KempNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chad M. Glen Todd C. McDevitt Melissa L. Kemp Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment
description	How heterogeneities arise in stem cell populations remains unclear. Here, Glen et al. find that in ESC colonies cell cycle asynchronies modulate gap junctions, causing variation in intracellular signalling molecule diffusion between cells, and ultimately in spatial heterogeneity in differentiation.
format	article
author	Chad M. Glen Todd C. McDevitt Melissa L. Kemp
author_facet	Chad M. Glen Todd C. McDevitt Melissa L. Kemp
author_sort	Chad M. Glen
title	Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment
title_short	Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment
title_full	Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment
title_fullStr	Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment
title_full_unstemmed	Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment
title_sort	dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/16b2365f5be44ed684389cdc6a17a6c0
work_keys_str_mv	AT chadmglen dynamicintercellulartransportmodulatesthespatialpatterningofdifferentiationduringearlyneuralcommitment AT toddcmcdevitt dynamicintercellulartransportmodulatesthespatialpatterningofdifferentiationduringearlyneuralcommitment AT melissalkemp dynamicintercellulartransportmodulatesthespatialpatterningofdifferentiationduringearlyneuralcommitment
_version_	1718390460762816512

Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment

Ejemplares similares