Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in <named-content content-type="genus-species">Staphylococcus aureus</named-content>

Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in <named-content content-type="genus-species">Staphylococcus aureus</named-content>

ABSTRACT Antistaphylococcal penicillins such as oxacillin are the key antibiotics in the treatment of invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections; however, mec gene-independent resistance adaptation can cause treatment failure. Despite its clinical relevance, the basis o...

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Bibliographic Details
Main Authors: Stefano G. Giulieri, Romain Guérillot, Jason C. Kwong, Ian R. Monk, Ashleigh S. Hayes, Diane Daniel, Sarah Baines, Norelle L. Sherry, Natasha E. Holmes, Peter Ward, Wei Gao, Torsten Seemann, Timothy P. Stinear, Benjamin P. Howden
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
Staphylococcus aureus
antibiotic resistance
β-lactams
genomics
Microbiology
QR1-502
Online Access:https://doaj.org/article/16e4fb535fb74b31acb798bc483a9ccc
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