Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources
Abstract Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resource...
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2021
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oai:doaj.org-article:1738ed6bfb2f4b5da6c969dfc52f92362021-12-02T14:27:02ZDescribing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources10.1038/s41598-021-82956-02045-2322https://doaj.org/article/1738ed6bfb2f4b5da6c969dfc52f92362021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82956-0https://doaj.org/toc/2045-2322Abstract Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a “One Health” perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources.Samuele BovoGiuseppina SchiavoAnisa RibaniValerio J. UtzeriValeria TaurisanoMohamad BallanMaria MuñozEstefania AlvesJose P. AraujoRiccardo BozziRui CharnecaFederica Di PalmaIvona Djurkin KušecGraham EtheringtonAna I. FernandezFabián GarcíaJuan García-CascoDanijel KarolyiMaurizio GalloJosé Manuel MartinsMarie-José MercatYolanda NúñezRaquel QuintanillaČedomir RadovićVioleta RazmaiteJuliette RiquetRadomir SavićMartin ŠkrlepGraziano UsaiChristoph ZimmerCristina OviloLuca FontanesiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
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Medicine R Science Q Samuele Bovo Giuseppina Schiavo Anisa Ribani Valerio J. Utzeri Valeria Taurisano Mohamad Ballan Maria Muñoz Estefania Alves Jose P. Araujo Riccardo Bozzi Rui Charneca Federica Di Palma Ivona Djurkin Kušec Graham Etherington Ana I. Fernandez Fabián García Juan García-Casco Danijel Karolyi Maurizio Gallo José Manuel Martins Marie-José Mercat Yolanda Núñez Raquel Quintanilla Čedomir Radović Violeta Razmaite Juliette Riquet Radomir Savić Martin Škrlep Graziano Usai Christoph Zimmer Cristina Ovilo Luca Fontanesi Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources |
| description |
Abstract Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a “One Health” perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources. |
| format |
article |
| author |
Samuele Bovo Giuseppina Schiavo Anisa Ribani Valerio J. Utzeri Valeria Taurisano Mohamad Ballan Maria Muñoz Estefania Alves Jose P. Araujo Riccardo Bozzi Rui Charneca Federica Di Palma Ivona Djurkin Kušec Graham Etherington Ana I. Fernandez Fabián García Juan García-Casco Danijel Karolyi Maurizio Gallo José Manuel Martins Marie-José Mercat Yolanda Núñez Raquel Quintanilla Čedomir Radović Violeta Razmaite Juliette Riquet Radomir Savić Martin Škrlep Graziano Usai Christoph Zimmer Cristina Ovilo Luca Fontanesi |
| author_facet |
Samuele Bovo Giuseppina Schiavo Anisa Ribani Valerio J. Utzeri Valeria Taurisano Mohamad Ballan Maria Muñoz Estefania Alves Jose P. Araujo Riccardo Bozzi Rui Charneca Federica Di Palma Ivona Djurkin Kušec Graham Etherington Ana I. Fernandez Fabián García Juan García-Casco Danijel Karolyi Maurizio Gallo José Manuel Martins Marie-José Mercat Yolanda Núñez Raquel Quintanilla Čedomir Radović Violeta Razmaite Juliette Riquet Radomir Savić Martin Škrlep Graziano Usai Christoph Zimmer Cristina Ovilo Luca Fontanesi |
| author_sort |
Samuele Bovo |
| title |
Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources |
| title_short |
Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources |
| title_full |
Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources |
| title_fullStr |
Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources |
| title_full_unstemmed |
Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources |
| title_sort |
describing variability in pig genes involved in coronavirus infections for a one health perspective in conservation of animal genetic resources |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1738ed6bfb2f4b5da6c969dfc52f9236 |
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