Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1

Satellite RNAs are aberrantly transcribed during pancreatic cancer progression. Here, the authors show that major satellite RNA binds to the multifunctional protein YBX1 in the cytoplasm and induces mutations in nuclear and mitochondrial DNA by preventing YBX1 stress-induced intracellular translocat...

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Autores principales:	Takahiro Kishikawa, Motoyuki Otsuka, Takeshi Yoshikawa, Motoko Ohno, Hideaki Ijichi, Kazuhiko Koike
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/173d08df061945b9a821dd66d44d0e58
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spelling	oai:doaj.org-article:173d08df061945b9a821dd66d44d0e582021-12-02T16:49:58ZSatellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX110.1038/ncomms130062041-1723https://doaj.org/article/173d08df061945b9a821dd66d44d0e582016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms13006https://doaj.org/toc/2041-1723Satellite RNAs are aberrantly transcribed during pancreatic cancer progression. Here, the authors show that major satellite RNA binds to the multifunctional protein YBX1 in the cytoplasm and induces mutations in nuclear and mitochondrial DNA by preventing YBX1 stress-induced intracellular translocation.Takahiro KishikawaMotoyuki OtsukaTakeshi YoshikawaMotoko OhnoHideaki IjichiKazuhiko KoikeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takahiro Kishikawa Motoyuki Otsuka Takeshi Yoshikawa Motoko Ohno Hideaki Ijichi Kazuhiko Koike Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1
description	Satellite RNAs are aberrantly transcribed during pancreatic cancer progression. Here, the authors show that major satellite RNA binds to the multifunctional protein YBX1 in the cytoplasm and induces mutations in nuclear and mitochondrial DNA by preventing YBX1 stress-induced intracellular translocation.
format	article
author	Takahiro Kishikawa Motoyuki Otsuka Takeshi Yoshikawa Motoko Ohno Hideaki Ijichi Kazuhiko Koike
author_facet	Takahiro Kishikawa Motoyuki Otsuka Takeshi Yoshikawa Motoko Ohno Hideaki Ijichi Kazuhiko Koike
author_sort	Takahiro Kishikawa
title	Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1
title_short	Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1
title_full	Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1
title_fullStr	Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1
title_full_unstemmed	Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1
title_sort	satellite rnas promote pancreatic oncogenic processes via the dysfunction of ybx1
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/173d08df061945b9a821dd66d44d0e58
work_keys_str_mv	AT takahirokishikawa satelliternaspromotepancreaticoncogenicprocessesviathedysfunctionofybx1 AT motoyukiotsuka satelliternaspromotepancreaticoncogenicprocessesviathedysfunctionofybx1 AT takeshiyoshikawa satelliternaspromotepancreaticoncogenicprocessesviathedysfunctionofybx1 AT motokoohno satelliternaspromotepancreaticoncogenicprocessesviathedysfunctionofybx1 AT hideakiijichi satelliternaspromotepancreaticoncogenicprocessesviathedysfunctionofybx1 AT kazuhikokoike satelliternaspromotepancreaticoncogenicprocessesviathedysfunctionofybx1
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Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1

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