Rational design of a nanoparticle platform for oral prophylactic immunotherapy to prevent immunogenicity of therapeutic proteins

Abstract The safety and efficacy of several life-saving therapeutic proteins are compromised due to their immunogenicity. Once a sustained immune response against a protein-based therapy is established, clinical options that are safe and cost-effective become limited. Prevention of immunogenicity of...

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Autores principales: Nhan H. Nguyen, Fiona Y. Glassman, Robert K. Dingman, Gautam N. Shenoy, Elizabeth A. Wohlfert, Jason G. Kay, Richard B. Bankert, Sathy V. Balu-Iyer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1786baa1e47743e4a012fbcf4ceadcfd
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