TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Reduced BMP receptor II signalling underlies pulmonary arterial hypertension (PAH). Here, Hurstet al. show that TNFα subverts BMP signalling by increasing BMP6 expression and signalling via an alternative BMP receptor, ALK2, in pulmonary artery smooth muscle cells to drive abnormal proliferation and...

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Autores principales:	Liam A. Hurst, Benjamin J. Dunmore, Lu Long, Alexi Crosby, Rafia Al-Lamki, John Deighton, Mark Southwood, Xudong Yang, Marko Z. Nikolic, Blanca Herrera, Gareth J. Inman, John R. Bradley, Amer A. Rana, Paul D. Upton, Nicholas W. Morrell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17874564742043b0848f710d036fb95a
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spelling	oai:doaj.org-article:17874564742043b0848f710d036fb95a2021-12-02T17:06:04ZTNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling10.1038/ncomms140792041-1723https://doaj.org/article/17874564742043b0848f710d036fb95a2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14079https://doaj.org/toc/2041-1723Reduced BMP receptor II signalling underlies pulmonary arterial hypertension (PAH). Here, Hurstet al. show that TNFα subverts BMP signalling by increasing BMP6 expression and signalling via an alternative BMP receptor, ALK2, in pulmonary artery smooth muscle cells to drive abnormal proliferation and PAH.Liam A. HurstBenjamin J. DunmoreLu LongAlexi CrosbyRafia Al-LamkiJohn DeightonMark SouthwoodXudong YangMarko Z. NikolicBlanca HerreraGareth J. InmanJohn R. BradleyAmer A. RanaPaul D. UptonNicholas W. MorrellNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liam A. Hurst Benjamin J. Dunmore Lu Long Alexi Crosby Rafia Al-Lamki John Deighton Mark Southwood Xudong Yang Marko Z. Nikolic Blanca Herrera Gareth J. Inman John R. Bradley Amer A. Rana Paul D. Upton Nicholas W. Morrell TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
description	Reduced BMP receptor II signalling underlies pulmonary arterial hypertension (PAH). Here, Hurstet al. show that TNFα subverts BMP signalling by increasing BMP6 expression and signalling via an alternative BMP receptor, ALK2, in pulmonary artery smooth muscle cells to drive abnormal proliferation and PAH.
format	article
author	Liam A. Hurst Benjamin J. Dunmore Lu Long Alexi Crosby Rafia Al-Lamki John Deighton Mark Southwood Xudong Yang Marko Z. Nikolic Blanca Herrera Gareth J. Inman John R. Bradley Amer A. Rana Paul D. Upton Nicholas W. Morrell
author_facet	Liam A. Hurst Benjamin J. Dunmore Lu Long Alexi Crosby Rafia Al-Lamki John Deighton Mark Southwood Xudong Yang Marko Z. Nikolic Blanca Herrera Gareth J. Inman John R. Bradley Amer A. Rana Paul D. Upton Nicholas W. Morrell
author_sort	Liam A. Hurst
title	TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
title_short	TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
title_full	TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
title_fullStr	TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
title_full_unstemmed	TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
title_sort	tnfα drives pulmonary arterial hypertension by suppressing the bmp type-ii receptor and altering notch signalling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/17874564742043b0848f710d036fb95a
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TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

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