Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins

Many diseases are caused by single-nucleotide polymorphisms. Here, the authors present CRISPR base editors that use the base excision machinery for single-base transversions.

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Detalles Bibliográficos
Autores principales:	Liwei Chen, Jung Eun Park, Peter Paa, Priscilla D. Rajakumar, Hong-Ting Prekop, Yi Ting Chew, Swathi N. Manivannan, Wei Leong Chew
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/179d414f933d4b028a782187beb2408e
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spelling	oai:doaj.org-article:179d414f933d4b028a782187beb2408e2021-12-02T13:14:48ZProgrammable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins10.1038/s41467-021-21559-92041-1723https://doaj.org/article/179d414f933d4b028a782187beb2408e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21559-9https://doaj.org/toc/2041-1723Many diseases are caused by single-nucleotide polymorphisms. Here, the authors present CRISPR base editors that use the base excision machinery for single-base transversions.Liwei ChenJung Eun ParkPeter PaaPriscilla D. RajakumarHong-Ting PrekopYi Ting ChewSwathi N. ManivannanWei Leong ChewNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liwei Chen Jung Eun Park Peter Paa Priscilla D. Rajakumar Hong-Ting Prekop Yi Ting Chew Swathi N. Manivannan Wei Leong Chew Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins
description	Many diseases are caused by single-nucleotide polymorphisms. Here, the authors present CRISPR base editors that use the base excision machinery for single-base transversions.
format	article
author	Liwei Chen Jung Eun Park Peter Paa Priscilla D. Rajakumar Hong-Ting Prekop Yi Ting Chew Swathi N. Manivannan Wei Leong Chew
author_facet	Liwei Chen Jung Eun Park Peter Paa Priscilla D. Rajakumar Hong-Ting Prekop Yi Ting Chew Swathi N. Manivannan Wei Leong Chew
author_sort	Liwei Chen
title	Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins
title_short	Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins
title_full	Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins
title_fullStr	Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins
title_full_unstemmed	Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins
title_sort	programmable c:g to g:c genome editing with crispr-cas9-directed base excision repair proteins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/179d414f933d4b028a782187beb2408e
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Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins

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