Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins

Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins

Many diseases are caused by single-nucleotide polymorphisms. Here, the authors present CRISPR base editors that use the base excision machinery for single-base transversions.

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Detalles Bibliográficos
Autores principales: Liwei Chen, Jung Eun Park, Peter Paa, Priscilla D. Rajakumar, Hong-Ting Prekop, Yi Ting Chew, Swathi N. Manivannan, Wei Leong Chew
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/179d414f933d4b028a782187beb2408e
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