Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

How cancer cells engage the microenvironment to establish metastasis is poorly understood. Here, the authors show that CXCR3-expressing breast cancer cells secrete IL-1 to induce a paracrine crosstalk with fibroblasts in the lung, which involves CXCL9/10 production and results in colonization of the...

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Main Authors: Maren Pein, Jacob Insua-Rodríguez, Tsunaki Hongu, Angela Riedel, Jasmin Meier, Lena Wiedmann, Kristin Decker, Marieke A. G. Essers, Hans-Peter Sinn, Saskia Spaich, Marc Sütterlin, Andreas Schneeweiss, Andreas Trumpp, Thordur Oskarsson
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/17acb7c31f7941f0959b5034c6bfd4bc
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https://doaj.org/article/17acb7c31f7941f0959b5034c6bfd4bc

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