Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice.

The use of genetically modified mice, i.e. transgenic as well as gene knockout (KO) and knock-in mice, has become an established tool to study gene function in many animal models for human diseases. However, a gene functions in a particular genomic context. This implies the importance of a well-defi...

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Autores principales: Nathalie Geurts, Erik Martens, Sebastien Verhenne, Natacha Lays, Greet Thijs, Stefan Magez, Bénédicte Cauwe, Sandra Li, Hubertine Heremans, Ghislain Opdenakker, Philippe E Van den Steen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/17c23f85bcdb468db28ebdc787e462a0
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