Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice.
The use of genetically modified mice, i.e. transgenic as well as gene knockout (KO) and knock-in mice, has become an established tool to study gene function in many animal models for human diseases. However, a gene functions in a particular genomic context. This implies the importance of a well-defi...
Guardado en:
Autores principales: | Nathalie Geurts, Erik Martens, Sebastien Verhenne, Natacha Lays, Greet Thijs, Stefan Magez, Bénédicte Cauwe, Sandra Li, Hubertine Heremans, Ghislain Opdenakker, Philippe E Van den Steen |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2011
|
Materias: | |
Acceso en línea: | https://doaj.org/article/17c23f85bcdb468db28ebdc787e462a0 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Relaxation of Some Confusions about Confounders
por: Ádám Zlatniczki, et al.
Publicado: (2021) -
AUTHORITARIANISM IN THE CENTRAL ASIA (AS EXEMPLIFIED BY KAZAKHSTAN)
por: V. V. Evseev
Publicado: (2013) -
Heterogeneity Confounds Establishment of “a” Model Microbial Strain
por: Nancy P. Keller
Publicado: (2017) -
Genetic sensitivity analysis: Adjusting for genetic confounding in epidemiological associations.
por: Jean-Baptiste Pingault, et al.
Publicado: (2021) -
Training confounder-free deep learning models for medical applications
por: Qingyu Zhao, et al.
Publicado: (2020)