Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission

Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission

Abstract The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride concentrations regulated by Na+-K+-2Cl− cotransporter...

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Main Authors: Anna Doshina, Florian Gourgue, Michiho Onizuka, Remi Opsomer, Peng Wang, Kunie Ando, Bernadette Tasiaux, Ilse Dewachter, Pascal Kienlen-Campard, Jean-Pierre Brion, Philippe Gailly, Jean-Noël Octave, Nathalie Pierrot
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/17df00cf26f446d68bc775b9993f6c1a
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