Structure-guided microbial targeting of antistaphylococcal prodrugs

Structure-guided microbial targeting of antistaphylococcal prodrugs

Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However, many carboxy ester promoieties are rapidly hydroly...

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Détails bibliographiques
Auteurs principaux: Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Geoffrey C Hoops, R Jeremy Johnson, Paul J Planet, Florian L Muller, Joseph M Jez, Audrey R Odom John
Format: article
Langue:EN
Publié: eLife Sciences Publications Ltd 2021
Sujets:
Staphylococcus aureus
antibacterial
prodrug
drug discovery
esterase
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/17f733fe025245b6a2dbe45ff732edb9
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Internet

https://doaj.org/article/17f733fe025245b6a2dbe45ff732edb9

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