Structure-guided microbial targeting of antistaphylococcal prodrugs

Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However, many carboxy ester promoieties are rapidly hydroly...

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Autores principales:	Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Geoffrey C Hoops, R Jeremy Johnson, Paul J Planet, Florian L Muller, Joseph M Jez, Audrey R Odom John
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	Staphylococcus aureus antibacterial prodrug drug discovery esterase Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/17f733fe025245b6a2dbe45ff732edb9
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Structure-guided microbial targeting of antistaphylococcal prodrugs

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