Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers
In the classic two-hit model, both alleles of a tumour suppressor gene need to be inactivated in order to promote cancer. Here, the authors challenge this model, finding that many cancer genes can be either one-hit or two-hit drivers depending on the context and other mutations in a tumor.
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/18060ce218734a20a7039fa9bacb0dac |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|