Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers

In the classic two-hit model, both alleles of a tumour suppressor gene need to be inactivated in order to promote cancer. Here, the authors challenge this model, finding that many cancer genes can be either one-hit or two-hit drivers depending on the context and other mutations in a tumor.

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Detalles Bibliográficos
Autores principales:	Solip Park, Fran Supek, Ben Lehner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/18060ce218734a20a7039fa9bacb0dac
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id	oai:doaj.org-article:18060ce218734a20a7039fa9bacb0dac
record_format	dspace
spelling	oai:doaj.org-article:18060ce218734a20a7039fa9bacb0dac2021-12-05T12:22:50ZHigher order genetic interactions switch cancer genes from two-hit to one-hit drivers10.1038/s41467-021-27242-32041-1723https://doaj.org/article/18060ce218734a20a7039fa9bacb0dac2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27242-3https://doaj.org/toc/2041-1723In the classic two-hit model, both alleles of a tumour suppressor gene need to be inactivated in order to promote cancer. Here, the authors challenge this model, finding that many cancer genes can be either one-hit or two-hit drivers depending on the context and other mutations in a tumor.Solip ParkFran SupekBen LehnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Solip Park Fran Supek Ben Lehner Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers
description	In the classic two-hit model, both alleles of a tumour suppressor gene need to be inactivated in order to promote cancer. Here, the authors challenge this model, finding that many cancer genes can be either one-hit or two-hit drivers depending on the context and other mutations in a tumor.
format	article
author	Solip Park Fran Supek Ben Lehner
author_facet	Solip Park Fran Supek Ben Lehner
author_sort	Solip Park
title	Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers
title_short	Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers
title_full	Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers
title_fullStr	Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers
title_full_unstemmed	Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers
title_sort	higher order genetic interactions switch cancer genes from two-hit to one-hit drivers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/18060ce218734a20a7039fa9bacb0dac
work_keys_str_mv	AT solippark higherordergeneticinteractionsswitchcancergenesfromtwohittoonehitdrivers AT fransupek higherordergeneticinteractionsswitchcancergenesfromtwohittoonehitdrivers AT benlehner higherordergeneticinteractionsswitchcancergenesfromtwohittoonehitdrivers
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Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers

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