Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers

In the classic two-hit model, both alleles of a tumour suppressor gene need to be inactivated in order to promote cancer. Here, the authors challenge this model, finding that many cancer genes can be either one-hit or two-hit drivers depending on the context and other mutations in a tumor.

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Autores principales: Solip Park, Fran Supek, Ben Lehner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/18060ce218734a20a7039fa9bacb0dac
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